MLB picks today for September 12, 2026: all 15 games on the board with a straight winner pick on each, plus the best number we could find across the major books — plus first-inning YRFI/NRFI leans for every matchup with confirmed starters. No standout value on today’s board — the market is pricing these tight, so shop the reference numbers below.
Table of Contents
Full MLB Slate
| Time | Matchup | Pick | Total | Best number | Starters | 1st inning |
|---|---|---|---|---|---|---|
| 1:10 PM ET | Colorado Rockies @ Detroit Tigers | Detroit Tigers (66%) | Over 8.5 (57%) FLIP | Detroit Tigers -168 (LowVig.ag) | Tanner Gordon (5.40 ERA) v Andrew Sears (4.38 ERA) | YRFI▲ (56%) |
| 1:36 PM ET | New York Mets @ New York Yankees | New York Yankees (65%) | Over 8 (52%) | New York Mets +160 (BetOnline.ag) | Zac Thornton (3.53 ERA) v Gerrit Cole (3.41 ERA) | YRFI (52%) |
| 2:21 PM ET | Pittsburgh Pirates @ Chicago Cubs | Chicago Cubs (59%) | Over 9 (50%) | Chicago Cubs -120 (LowVig.ag) | Paul Skenes (3.83 ERA) v Clay Holmes (2.83 ERA) | NRFI (55%) |
| 3:08 PM ET | Baltimore Orioles @ Toronto Blue Jays | Toronto Blue Jays (54%) | Under 8.5 (52%) | Baltimore Orioles +102 (LowVig.ag) | Kyle Bradish (3.91 ERA) v Spencer Miles (2.77 ERA) | NRFI▲ (68%) |
| 4:06 PM ET | San Diego Padres @ San Francisco Giants | San Francisco Giants (51%) MODEL FLIP | Under 8 (56%) | San Francisco Giants +143 (BetOnline.ag) | Michael King (3.00 ERA) v Cesar Perdomo (0.90 ERA) | NRFI▲ (75%) |
| 4:06 PM ET | Los Angeles Angels @ Washington Nationals | Washington Nationals (55%) | Over 8 (54%) | Washington Nationals -111 (BetOnline.ag) | Walbert Ureña (2.74 ERA) v Andrew Alvarez (3.60 ERA) | NRFI▲ (66%) |
| 4:11 PM ET | Kansas City Royals @ Boston Red Sox | Boston Red Sox (63%) | Under 8.5 (51%) | Kansas City Royals +180 (BetRivers) | Randy Dobnak (2.54 ERA) v Ranger Suarez (3.44 ERA) | NRFI▲ (60%) |
| 4:11 PM ET | Cleveland Guardians @ Minnesota Twins | Cleveland Guardians (53%) MODEL FLIP | Under 9 (55%) | Minnesota Twins -104 (FanDuel) | Daniel Espino (2.70 ERA) v Connor Prielipp (5.25 ERA) | YRFI▲ (56%) |
| 4:11 PM ET | Los Angeles Dodgers @ Miami Marlins | Los Angeles Dodgers (61%) | Under 8 (51%) | Miami Marlins +169 (LowVig.ag) | Tyler Glasnow (3.12 ERA) v Tyler Phillips (3.51 ERA) | NRFI (54%) |
| 6:11 PM ET | Houston Astros @ Tampa Bay Rays | Tampa Bay Rays (58%) | Over 7.5 (55%) | Tampa Bay Rays -141 (LowVig.ag) | Peter Lambert (3.67 ERA) v Ian Seymour (4.33 ERA) | NRFI▲ (57%) |
| 7:11 PM ET | Cincinnati Reds @ Milwaukee Brewers | Milwaukee Brewers (70%) | Over 8.5 (52%) FLIP | Cincinnati Reds +162 (MyBookie.ag) | TBD | — |
| 7:16 PM ET | Philadelphia Phillies @ Atlanta Braves | Atlanta Braves (57%) | Over 8 (52%) | Philadelphia Phillies +113 (BetUS) | TBD | — |
| 7:16 PM ET | Chicago White Sox @ St. Louis Cardinals | Chicago White Sox (50%) MODEL FLIP | Under 8.5 (52%) | St. Louis Cardinals -110 (LowVig.ag) | Sean Newcomb (2.71 ERA) v Kyle Leahy (3.41 ERA) | NRFI▲ (60%) |
| 8:11 PM ET | Texas Rangers @ Arizona Diamondbacks | Arizona Diamondbacks (59%) | Over 8.5 (52%) | Arizona Diamondbacks -135 (LowVig.ag) | Kumar Rocker (4.61 ERA) v Brandon Pfaadt (3.53 ERA) | YRFI▲ (61%) |
| 9:41 PM ET | Seattle Mariners @ Athletics | Seattle Mariners (57%) | Under 9.5 (53%) FLIP | Athletics +150 (FanDuel) | Bryan Woo (4.03 ERA) v Gage Jump (5.12 ERA) | YRFI▲ (56%) |
Over / Under Board
- Over 8.5 — Colorado Rockies @ Detroit Tigers: our number is 9.8, so we make it 57% to land over — against the posted total.
- Under 8 — San Diego Padres @ San Francisco Giants: our number is 6.82, so we make it 56% to land under.
- Over 7.5 — Houston Astros @ Tampa Bay Rays: our number is 8.33, so we make it 55% to land over.
- Under 9 — Cleveland Guardians @ Minnesota Twins: our number is 8.27, so we make it 55% to land under.
- Over 8 — Los Angeles Angels @ Washington Nationals: our number is 8.72, so we make it 54% to land over.
- Under 9.5 — Seattle Mariners @ Athletics: our number is 8.95, so we make it 53% to land under — against the posted total.
YRFI / NRFI Leans
Seventy-five percent lean and the arms back it up cold, Perdomo’s been untouchable and King’s not far behind. Easiest lean on the board, first inning stays scoreless here.
- YRFI Colorado Rockies @ Detroit Tigers — 56% chance of a first-inning run (Tanner Gordon (5.40 ERA) vs Andrew Sears (4.38 ERA))
- YRFI New York Mets @ New York Yankees — 52% chance of a first-inning run (Zac Thornton (3.53 ERA) vs Gerrit Cole (3.41 ERA))
- NRFI Pittsburgh Pirates @ Chicago Cubs — 55% chance the first inning stays scoreless (Paul Skenes (3.83 ERA) vs Clay Holmes (2.83 ERA))
- NRFI Baltimore Orioles @ Toronto Blue Jays — 68% chance the first inning stays scoreless (Kyle Bradish (3.91 ERA) vs Spencer Miles (2.77 ERA))
- NRFI Los Angeles Angels @ Washington Nationals — 66% chance the first inning stays scoreless (Walbert Ureña (2.74 ERA) vs Andrew Alvarez (3.60 ERA))
- NRFI San Diego Padres @ San Francisco Giants — 75% chance the first inning stays scoreless (Michael King (3.00 ERA) vs Cesar Perdomo (0.90 ERA))
- NRFI Kansas City Royals @ Boston Red Sox — 60% chance the first inning stays scoreless (Randy Dobnak (2.54 ERA) vs Ranger Suarez (3.44 ERA))
- YRFI Cleveland Guardians @ Minnesota Twins — 56% chance of a first-inning run (Daniel Espino (2.70 ERA) vs Connor Prielipp (5.25 ERA))
- NRFI Los Angeles Dodgers @ Miami Marlins — 54% chance the first inning stays scoreless (Tyler Glasnow (3.12 ERA) vs Tyler Phillips (3.51 ERA))
- NRFI Houston Astros @ Tampa Bay Rays — 57% chance the first inning stays scoreless (Peter Lambert (3.67 ERA) vs Ian Seymour (4.33 ERA))
- NRFI Chicago White Sox @ St. Louis Cardinals — 60% chance the first inning stays scoreless (Sean Newcomb (2.71 ERA) vs Kyle Leahy (3.41 ERA))
- YRFI Texas Rangers @ Arizona Diamondbacks — 61% chance of a first-inning run (Kumar Rocker (4.61 ERA) vs Brandon Pfaadt (3.53 ERA))
- YRFI Seattle Mariners @ Athletics — 56% chance of a first-inning run (Bryan Woo (4.03 ERA) vs Gage Jump (5.12 ERA))
New to first-inning markets? Start with our guide: NRFI and YRFI, explained.
How we read these boards: how to read a matchup.
The Pick comes from our power ratings — season scoring differential, strength-adjusted matchup math, and home edge — blended with the market’s no-vig fair price; the number shown is that blend’s win probability. The Total is built the same way: we estimate each side’s scoring from what these teams score and concede (for baseball, adjusted for the listed starters and the ballpark), recentre that estimate against the day’s posted numbers so a modelling bias can’t tilt the whole board, and compare it to the line. A MODEL FLIP means our ratings like the side the market has as the underdog. A “VALUE” tag is a different thing: it means the best available number beats the fair price by 3–12% (sometimes that value sits on the side we don’t pick to win — a good price and a likely winner aren’t always the same bet). These are leans, not locks — decision support for bets you were already considering, on whatever book or market you use. Lines move; check the current number before you do anything.
21+. Please play responsibly. If it stops being fun: 1-800-GAMBLER. Get this board by email every morning — the BetSlate Briefing.